@bbense I am exactly the same. A company that I previously worked at started me off with a straight keyboard and after a few weeks I could barely type. However I can use my laptop at home for hours on end regularly without issue.
I also know a guy that (IIRC) suffered carpel tunnel and now uses one of these to prevent any issues, but can use a laptop just fine.
I have always assumed the difference with a laptop keyboard is because my hands are positioned more on top of the keyboard instead of reaching onto something that's higher than the surface my wrists are resting on.